Projects and Activities

SUPPORTING T1D RESEARCH

The Bioinformatics Center is designed to be a collaborative partner in support of research being conducted by HIRN investigators. If we do not possess the right tools or lack the resources to help, we will find someone with the proper expertise who can assist you. Examples of past and current activities are listed below.

PUBLICATIONS

The following list of published studies acknowledge the Bioinformatics Center and/or includes its members as study co-authors on HIRN supported research.

  1. Kusmartseva I, Beery M, Philips T, Selman S, Jadhav P, Wasserfall C, Muller A, Pugliese A, Longmate JA, Schatz DA, Atkinson MA, Kaddis JS. Hospital time prior to death and pancreas histopathology: implications for future studies. Diabetologia. 2018 Apr; 61(4):954-958.
  2. Babon, JA; DeNicola, ME; Blodgett, DM; Crèvecoeur, I; Buttrick, TS; Maehr, R; Bottino, R; Naji, A; Kaddis, J; Elyaman, W; James, EA; Haliyur, R; Brissova, M; Overbergh, L; Mathieu, C; Delong, T; Haskins, K; Pugliese, A; Campbell-Thompson, M; Mathews, C; Atkinson, MA; Powers, AC; Harlan, DM; Kent, SC. Corrigendum: Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes. Nat Med, 2017 Feb; 23(2):264.
  3. Babon, JA; DeNicola, ME; Blodgett, DM; Crèvecoeur, I; Buttrick, TS; Maehr, R; Bottino, R; Naji, A; Kaddis, J; Elyaman, W; James, EA; Haliyur, R; Brissova, M; Overbergh, L; Mathieu, C; Delong, T; Haskins, K; Pugliese, A; Campbell-Thompson, M; Mathews, C; Atkinson, MA; Powers, AC; Harlan, DM; Kent, SC. Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes. Nat Med, 2016 Dec; 22(12):1482-1487.
  4. Seay, H.R.; Yusko, E.; Rothweiler, S.J.; Zhang, L.; Posgai, A.L.; Campbell-Thompson, M.; Vignali, M.; Emerson R.; Kaddis, J.S.; Ko, D.; Nakayama, M.; Smith, M.J.; Cambier, J.C.; Pugliese, A.; Atkinson, M.A.; Robins, H.S.; Brusko, T.M. Tissue Distribution and Clonal Diversity of the T and B cell Repertoire in Type 1 Diabetes. JCI Insight, 2016 Dec; 1(20):e88242.
  5. Philips, T; Kusmartseva, I.; Gerling, I.C.; Campbell-Thompson, M.; Nick, H.S.; Wasserfall, C; Pugliese, A.; Longmate, J.A.; Schatz, D.; Atkinson, M.A.; Kaddis, J.S. Factors that Influence the Quality of RNA from the Pancreas of Organ Donors. Pancreas, 2017 Feb; 46(2): 252-259.
  6. Richardson, S.J.; Rodriguez-Calvo, T.; Gerling, I.C.; Mathews, C.E.; Kaddis, J.S.; Russell, M.A.; Zeissler, M.; Lette, P.; Krogvold, L.; Dahl-Jorgensen, K.; von Herrath, M.; Pugliese, A.; Atkinson, M.A.; Morgan, N.G. Islet Cell Hyperexpression of HLA Class I Antigens: A Defining Feature Critical to Beta Cell Loss in Type 1 Diabetes. Diabetelogia, 2016 Nov; 59(11):2448-58.
  7. Campbell-Thompson, M.; Fu, A,; Kaddis, J.S.; Wasserfall, C.; Schatz, D.A.; Pugliese, A.; Atkinson M.A. Insulitis and β-Cell Mass in the Natural History of Type 1 Diabetes. Diabetes. 2016 Mar; 65(3):719-31.

Who We Are & What We Do

From resource sharing and data analysis to computational infrastructure, we support type 1 diabetes research.

Supported & Developed Software

Access tools for hosting, moving, sharing, and analysis of data.

Connect With Us

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